association between helicobacter pylori caga, baba2 virulence factors and gastric mucosal interleukin-33 mrna expression and clinical outcomes in dyspeptic patients
نویسندگان
چکیده
helicobacter pylori (h. pylori) infection has been reported in more than half of the world human population. it is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. il-1β, il-18 have been shown to contribute to h. pylori induced gastritis, but the details of inflammation and association of virulence factors remain unclear. il-1 cytokine family has a new additional cytokine, interleukin-33 (il-33), which is contemplated to have an important role for host defense against microorganisms. h. pylori virulence factors important in gastritis risk are the cag pathogenicity island (cag-pai) and baba. this study evaluated il-33 mucosal mrna expression levels in infected and uninfected patients and its relationship with bacterial virulence factors caga, baba2 and type of gastritis. total rna was extracted from gastric biopsies of 79 h. pylori-infected patients and 51 h. pylori-negative patients. mucosal il-33 mrna expression levels in gastric biopsies were assessed using real-time pcr. existence of virulence factors were detected by pcr. il-33 mrna expression was significantly higher in biopsies of h. pylori-infected patients compared to h. pylori-uninfected patients (p< 0.0001). also there was a direct relationship between virulence factor bab-a2 and enhancement in il-33 mrna expression. furthermore, il-33 mrna expression level was significantly lower in chronic gastritis patients compared with patients with active gastritis (p< 0.001). il-33 may play a crucial role in the inflammatory response and induction of the chronic gastritis and severity of inflammatory changes in the gastric mucosa.
منابع مشابه
Association between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients
Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1&beta, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence fac...
متن کاملAssociation Between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients
Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1β, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence factors...
متن کاملAssociation between virulence factors of helicobacter pylori and gastric mucosal interleukin-18 mRNA expression in dyspeptic patients.
BACKGROUND Helicobacter pylori (Hp) infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells that contribute to sustain and expand the local inflammation. Different clinical expressions of the infection may reflect distinctive patterns of cytokine expression. IL-1β, TNF-α, IL-17 and IL-23 have been reported to be invo...
متن کاملAssociation of the virulence factors of Helicobacter pylori and gastric mucosal interleukin-17/23 mRNA expression in dyspeptic patients
The molecular pathways that control Helicobacter pylori (Hp)-associated inflammatory reaction are complex, but locally induced cytokines and virulence factors seem to have a major role in maintaining the ongoing inflammation. Therefore this study was aimed to evaluate the association of the virulence factors of Hp and gastric mucosal interleukin-17/23 mRNA expression in dyspeptic patients. Muco...
متن کاملThe Role of Helicobacter Pylori Virulence Factors in Gastric Cancer
Introduction: Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the v...
متن کاملAssociation between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan
BACKGROUND Specific genotypes of several virulence factors of Helicobacter pylori (eg, cagA-positive, vacA s1, oipA "on" and babA-positive) have been reported to be predictors of severe clinical outcomes. Importantly, the presence of these genotypes correlates with each other. We hypothesized that novel virulence genes correlate with the presence of cagA. Therefore, we aimed to find novel candi...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of molecular and cellular medicineجلد ۴، شماره ۴، صفحات ۲۲۷-۲۳۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023